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Extending the σ-Hole Motif for Sequence Specific Recognition of the DNA Minor Groove

The majority of current drugs against diseases, such as cancer, can bind to one or more sites in a protein and inhibit its activity. There are, however, well known limits on the number of druggable proteins and complementing current drugs with compounds that could selectively target DNA or RNA would...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Guo, Pu, Farahat, Abdelbasset A., Paul, Ananya, Kumar, Arvind, Boykin, David W., Wilson, W. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849046/
https://ncbi.nlm.nih.gov/pubmed/32293884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00090
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