A Modular Design for Minor Groove Binding and Recognition of Mixed Base Pair Sequences of DNA

The design and synthesis of compounds that target mixed, AT/GC, DNA sequences is described. The design concept connects two N-methyl-benzimidazole-thiophene single GC recognition units with a flexible linker that lets the compound fit the shape and twist of the DNA minor groove while covering a full...

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Veröffentlicht in:Chem Commun (Camb)
Hauptverfasser: Guo, Pu, Paul, Ananya, Kumar, Arvind, Harika, Narinder K., Wang, Siming, Farahat, Abdelbasset A., Boykin, David W., Wilson, W. David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5616130/
https://ncbi.nlm.nih.gov/pubmed/28880316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc06246j
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