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Imino proton NMR guides the reprogramming of A•T specific minor groove binders for mixed base pair recognition
Sequence-specific binding to DNA is crucial for targeting transcription factor-DNA complexes to modulate gene expression. The heterocyclic diamidine, DB2277, specifically recognizes a single G•C base pair in the minor groove of mixed base pair sequences of the type AAAGTTT. NMR spectroscopy reveals...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889958/ https://ncbi.nlm.nih.gov/pubmed/27131382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw353 |
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