The Thiophene “Sigma-Hole” as a Concept for Preorganized, Specific Recognition of G•C Base Pairs in the DNA Minor Groove

In spite of its importance in cell function, targeting DNA is under-represented in the design of small molecules. A barrier to progress in this area is the lack of a variety of modules that recognize G•C base pairs (bp) in DNA sequences. To overcome this barrier an entirely new design concept for mo...

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Vydáno v:Chemistry
Hlavní autoři: Guo, Pu, Paul, Ananya, Kumar, Arvind, Farahat, Abdelbasset A., Kumar, Dhiraj, Wang, Siming, Boykin, David W., Wilson, W. David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214980/
https://ncbi.nlm.nih.gov/pubmed/27624927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201603422
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