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Resolution of mixed site DNA complexes with dimer-forming minor groove binders by using electrospray ionization mass spectrometry: Compound structure and DNA sequence effects

Small molecule targeting of the DNA minor groove is a promising approach to modulate genomic processes necessary for normal cellular function. For instance, dicationic diamindines, a well-known class of minor groove binding compounds, have been shown to inhibit interactions of transcription factors...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Laughlin, Sarah, Wang, Siming, Kumar, Arvind, Farahat, Abdelbasset A., Boykin, David W., Wilson, W. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732565/
https://ncbi.nlm.nih.gov/pubmed/25703690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201406322
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