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A novel approach using electrospray ionization mass spectrometry to study competitive binding of small molecules with mixed DNA sequences
Minor groove binding compounds have been shown to induce changes in global DNA conformation, allosterically inhibiting DNA-protein interactions necessary for transcriptional processes. Many minor groove binders are specific for AT-base pairs but have little preference over alternating AT or A-tract...
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| Published in: | Anal Bioanal Chem |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4339222/ https://ncbi.nlm.nih.gov/pubmed/25074546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-014-8044-9 |
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