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The Thiophene “Sigma-Hole” as a Concept for Preorganized, Specific Recognition of G•C Base Pairs in the DNA Minor Groove
In spite of its importance in cell function, targeting DNA is under-represented in the design of small molecules. A barrier to progress in this area is the lack of a variety of modules that recognize G•C base pairs (bp) in DNA sequences. To overcome this barrier an entirely new design concept for mo...
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| Publicat a: | Chemistry |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5214980/ https://ncbi.nlm.nih.gov/pubmed/27624927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201603422 |
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