Structure of the forkhead domain of FOXA2 bound to a complete DNA consensus site

FOXA2, a member of the forkhead family of transcription factors, plays essential roles in liver development and bile acid homeostasis. In this study, we report a 2.8 Å co-crystal structure of the FOXA2 DNA-binding domain (FOXA2-DBD) bound to a DNA duplex containing a forkhead consensus binding site...

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Udgivet i:Biochemistry
Main Authors: Li, Jun, Machado, Ana Carolina Dantas, Guo, Ming, Sagendorf, Jared M., Zhou, Zhan, Jiang, Longying, Chen, Xiaojuan, Wu, Daichao, Qu, Lingzhi, Chen, Zhuchu, Chen, Lin, Rohs, Remo, Chen, Yongheng
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614898/
https://ncbi.nlm.nih.gov/pubmed/28644006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00211
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