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Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion
The p53 core domain binds to response elements (REs) that contain two continuous half-sites as a cooperative tetramer, but how p53 recognizes discontinuous REs is not well understood. Here we describe the crystal structure of the p53 core domain bound to a naturally occurring RE located at the promo...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3783167/ https://ncbi.nlm.nih.gov/pubmed/23836939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt584 |
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