Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion

The p53 core domain binds to response elements (REs) that contain two continuous half-sites as a cooperative tetramer, but how p53 recognizes discontinuous REs is not well understood. Here we describe the crystal structure of the p53 core domain bound to a naturally occurring RE located at the promo...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Chen, Yongheng, Zhang, Xiaojun, Dantas Machado, Ana Carolina, Ding, Yuan, Chen, Zhuchu, Qin, Peter Z., Rohs, Remo, Chen, Lin
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783167/
https://ncbi.nlm.nih.gov/pubmed/23836939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt584
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares