Conformations of p53 response elements in solution deduced using site-directed spin labeling and Monte Carlo sampling

The tumor suppressor protein p53 regulates numerous signaling pathways by specifically recognizing diverse p53 response elements (REs). Understanding the mechanisms of p53-DNA interaction requires structural information on p53 REs. However, such information is limited as a 3D structure of any RE in...

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Detalhes bibliográficos
Main Authors: Zhang, Xiaojun, Dantas Machado, Ana Carolina, Ding, Yuan, Chen, Yongheng, Lu, Yan, Duan, Yankun, Tham, Kenneth W., Chen, Lin, Rohs, Remo, Qin, Peter Z.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936745/
https://ncbi.nlm.nih.gov/pubmed/24293651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1219
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