Conformations of p53 response elements in solution deduced using site-directed spin labeling and Monte Carlo sampling

The tumor suppressor protein p53 regulates numerous signaling pathways by specifically recognizing diverse p53 response elements (REs). Understanding the mechanisms of p53-DNA interaction requires structural information on p53 REs. However, such information is limited as a 3D structure of any RE in...

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Hlavní autoři: Zhang, Xiaojun, Dantas Machado, Ana Carolina, Ding, Yuan, Chen, Yongheng, Lu, Yan, Duan, Yankun, Tham, Kenneth W., Chen, Lin, Rohs, Remo, Qin, Peter Z.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936745/
https://ncbi.nlm.nih.gov/pubmed/24293651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1219
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