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c-Src Binds to the Cancer Drug Ruxolitinib with an Active Conformation

The cancer drug Ruxolitinib is a potent janus kinase inhibitor approved for the treatment of the myeloproliferative neoplasms. In addition, Ruxolitinib has weak inhibitory activity against a panel of other kinases, including Src kinase. There is no structural information of Ruxolitinib binding to an...

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Detalhes bibliográficos
Main Authors: Duan, Yankun, Chen, Lin, Chen, Yongheng, Fan, Xue-gong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157781/
https://ncbi.nlm.nih.gov/pubmed/25197973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106225
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