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Unlatched BAX pairs for death
Self-interacting BAX proteins permeabilize outer mitochondrial membranes to trigger apoptotic cell death. Czabotar et al. present two revealing structures of BAX dimers, one dimer has an activator BH3-helix bound into its canonical cleft, and the other dimer exposes a planar hydrophobic face potenti...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3975071/ https://ncbi.nlm.nih.gov/pubmed/23374333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.01.018 |
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