Nucleophosmin, a Critical Bax Cofactor in Ischemia-Induced Cell Death

We hypothesized that nucleophosmin (NPM), a nucleolar phosphoprotein, is critical for Bax-mediated cell death. To test this hypothesis, Bax activation was induced by metabolic stress. During stress, nucleolar NPM translocated into the cytosol, NPM-Bax complexes formed, and both NPM and Bax accumulat...

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Bibliografiske detaljer
Main Authors: Wang, Zhiyong, Gall, Jonathan M., Bonegio, Ramon, Havasi, Andrea, Illanes, Katarina, Schwartz, John H., Borkan, Steven C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647959/
https://ncbi.nlm.nih.gov/pubmed/23459946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00015-13
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