Conditional Knockout of Proximal Tubule Mitofusin 2 Accelerates Recovery and Improves Survival after Renal Ischemia

Proximal tubule (PT) cells are critical targets of acute ischemic injury. Elimination of the mitochondrial fusion protein mitofusin 2 (Mfn2) sensitizes PT cells to apoptosis in vitro. However, the role of PT Mfn2 in ischemic AKI in vivo is unknown. To test its role, we evaluated the effects of condi...

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Bibliografiska uppgifter
I publikationen:J Am Soc Nephrol
Huvudupphovsmän: Gall, Jonathan M., Wang, Zhiyong, Bonegio, Ramon G., Havasi, Andrea, Liesa, Marc, Vemula, Pradheep, Borkan, Steven C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Nephrology 2015
Ämnen:
Basic Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413756/
https://ncbi.nlm.nih.gov/pubmed/25201884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014010126
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