Conditional Knockout of Proximal Tubule Mitofusin 2 Accelerates Recovery and Improves Survival after Renal Ischemia

Proximal tubule (PT) cells are critical targets of acute ischemic injury. Elimination of the mitochondrial fusion protein mitofusin 2 (Mfn2) sensitizes PT cells to apoptosis in vitro. However, the role of PT Mfn2 in ischemic AKI in vivo is unknown. To test its role, we evaluated the effects of condi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Am Soc Nephrol
Egile Nagusiak: Gall, Jonathan M., Wang, Zhiyong, Bonegio, Ramon G., Havasi, Andrea, Liesa, Marc, Vemula, Pradheep, Borkan, Steven C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Nephrology 2015
Gaiak:
Basic Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413756/
https://ncbi.nlm.nih.gov/pubmed/25201884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014010126
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak