Hexokinase Regulates Susceptibility to Bax-Mediated Mitochondrial Membrane Injury after Ischemic Stress

Hexokinase (HK), the rate-limiting enzyme in glycolysis, regulates cell survival either by promoting metabolism and/or inhibiting apoptosis. HKI and HKII, isoforms with mitochondrial targeting sequences, were studied in renal epithelial cells after ATP depletion, an insult that activates GSK3β and B...

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Главные авторы: Gall, Jonathan M., Wong, Vincent, Pimental, David, Havasi, Andrea, Wang, Zhiyong, Pastorino, John G., Bonegio, Ramon, Schwartz, John H., Borkan, Steven C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361076/
https://ncbi.nlm.nih.gov/pubmed/21430642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2010.532
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