Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455

Aberrant FGFR4 signaling has been documented abundantly in various human cancers. The majority of FGFR inhibitors display significantly reduced potency toward FGFR4 compared to FGFR1-3. However, LY2874455 has similar inhibition potency for FGFR1-4 with IC50 less than 6.4 nM. To date, there is no pub...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wu, Daichao, Guo, Ming, Philips, Michael A., Qu, Lingzhi, Jiang, Longying, Li, Jun, Chen, Xiaojuan, Chen, Zhuchu, Chen, Lin, Chen, Yongheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019380/
https://ncbi.nlm.nih.gov/pubmed/27618313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162491
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