Integrative Multi‐Omics Approaches Reveal Selectivity Profiles and Molecular Mechanisms of FIIN‐2, a Covalent FGFR Inhibitor

Abstract Fibroblast growth factor receptor (FGFR) inhibitors are emerged as an important class of targeted therapies in oncology, targeting key pathways associated with tumor growth, angiogenesis, and resistance to conventional treatments. FIIN‐2, the first irreversible covalent pan‐FGFR inhibitor,...

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Hlavní autoři:	Ying Fu, Dandan Zhu, Xiaojuan Chen, Lingzhi Qu, Ming Guo, Shuhong Zhang, Guangyu Xu, Zhuchu Chen, Maoyu Li, Yongheng Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2025-04-01
Edice:	Advanced Science
Témata:	AMPKα1 chemoproteomics FGFR inhibitor HCC multi‐omics
On-line přístup:	https://doi.org/10.1002/advs.202412578
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