Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455.

Aberrant FGFR4 signaling has been documented abundantly in various human cancers. The majority of FGFR inhibitors display significantly reduced potency toward FGFR4 compared to FGFR1-3. However, LY2874455 has similar inhibition potency for FGFR1-4 with IC50 less than 6.4 nM. To date, there is no pub...

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Bibliografski detalji

Glavni autori:	Daichao Wu, Ming Guo, Michael A Philips, Lingzhi Qu, Longying Jiang, Jun Li, Xiaojuan Chen, Zhuchu Chen, Lin Chen, Yongheng Chen
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2016-01-01
Serija:	PLoS ONE
Online pristup:	http://europepmc.org/articles/PMC5019380?pdf=render
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