Activin and Nodal Are Not Suitable Alternatives to TGFβ for Chondrogenic Differentiation of Mesenchymal Stem Cells

OBJECTIVE: Previously, we demonstrated the importance of transforming growth factor-β (TGFβ)-activated SMAD2/3 signaling in chondrogenesis of bone marrow–derived mesenchymal stem cells (BMSCs). However, TGFβ also signals via the SMAD1/5/9 pathway, which is known to induce terminal differentiation of...

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Detalhes bibliográficos
Publicado no:Cartilage
Main Authors: de Kroon, Laurie M. G., Davidson, Esmeralda N. Blaney, Narcisi, Roberto, Farrell, Eric, van der Kraan, Peter M., van Osch, Gerjo J. V. M.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
Assuntos:
Basic in vitro Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5613891/
https://ncbi.nlm.nih.gov/pubmed/28934877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947603516667585
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