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A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis

Transforming growth factor beta (TGFβ) is a growth factor with many faces. In our osteoarthritis (OA) research we have found that TGFβ can be protective as well as deleterious for articular cartilage. We postulate that the dual effects of TGFβ on chondrocytes can be explained by the fact that TGFβ c...

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Bibliographic Details
Main Authors: van der Kraan, Peter M, Blaney Davidson, Esmeralda N, van den Berg, Wim B
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875624/
https://ncbi.nlm.nih.gov/pubmed/20156325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2896
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