Age-dependent alteration of TGF-β signalling in osteoarthritis

Osteoarthritis (OA) is a disease of articular cartilage, with aging as the main risk factor. In OA, changes in chondrocytes lead to the autolytic destruction of cartilage. Transforming growth factor-β has recently been demonstrated to signal not only via activin receptor-like kinase 5 (ALK5)-induced...

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Hlavní autoři: van der Kraan, Peter M., Goumans, Marie-José, Blaney Davidson, Esmeralda, ten Dijke, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer-Verlag 2011
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250613/
https://ncbi.nlm.nih.gov/pubmed/21638205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00441-011-1194-6
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