Activin Receptor-Like Kinase Receptors ALK5 and ALK1 Are Both Required for TGFβ-Induced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

INTRODUCTION: Bone marrow-derived mesenchymal stem cells (BMSCs) are promising for cartilage regeneration because BMSCs can differentiate into cartilage tissue-producing chondrocytes. Transforming Growth Factor β (TGFβ) is crucial for inducing chondrogenic differentiation of BMSCs and is known to si...

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Veröffentlicht in:PLoS One
Hauptverfasser: de Kroon, Laurie M. G., Narcisi, Roberto, Blaney Davidson, Esmeralda N., Cleary, Mairéad A., van Beuningen, Henk M., Koevoet, Wendy J. L. M., van Osch, Gerjo J. V. M., van der Kraan, Peter M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697836/
https://ncbi.nlm.nih.gov/pubmed/26720610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146124
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