Long-Term Expansion, Enhanced Chondrogenic Potential, and Suppression of Endochondral Ossification of Adult Human MSCs via WNT Signaling Modulation

Mesenchymal stem cells (MSCs) are a potential source of chondrogenic cells for the treatment of cartilage disorders, but loss of chondrogenic potential during in vitro expansion and the propensity of cartilage to undergo hypertrophic maturation impede their therapeutic application. Here we report th...

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Publicado no:Stem Cell Reports
Main Authors: Narcisi, Roberto, Cleary, Mairéad A., Brama, Pieter A.J., Hoogduijn, Martin J., Tüysüz, Nesrin, ten Berge, Derk, van Osch, Gerjo J.V.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375944/
https://ncbi.nlm.nih.gov/pubmed/25733021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.01.017
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