Long-Term Expansion, Enhanced Chondrogenic Potential, and Suppression of Endochondral Ossification of Adult Human MSCs via WNT Signaling Modulation

Mesenchymal stem cells (MSCs) are a potential source of chondrogenic cells for the treatment of cartilage disorders, but loss of chondrogenic potential during in vitro expansion and the propensity of cartilage to undergo hypertrophic maturation impede their therapeutic application. Here we report th...

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Bibliographic Details
Published in:Stem Cell Reports
Main Authors: Narcisi, Roberto, Cleary, Mairéad A., Brama, Pieter A.J., Hoogduijn, Martin J., Tüysüz, Nesrin, ten Berge, Derk, van Osch, Gerjo J.V.M.
Format: Artigo
Language:Inglês
Published: Elsevier 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375944/
https://ncbi.nlm.nih.gov/pubmed/25733021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.01.017
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