Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi

Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and mitogen-activated p...

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Publicado en:Nat Commun
Autores principales: Yeh, Iwei, Lang, Ursula E., Durieux, Emeline, Tee, Meng Kian, Jorapur, Aparna, Shain, A. Hunter, Haddad, Veronique, Pissaloux, Daniel, Chen, Xu, Cerroni, Lorenzo, Judson, Robert L., LeBoit, Philip E., McCalmont, Timothy H., Bastian, Boris C., de la Fouchardière, Arnaud
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608693/
https://ncbi.nlm.nih.gov/pubmed/28935960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00758-3
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