Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi

Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and mitogen-activated p...

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Udgivet i:Nat Commun
Main Authors: Yeh, Iwei, Lang, Ursula E., Durieux, Emeline, Tee, Meng Kian, Jorapur, Aparna, Shain, A. Hunter, Haddad, Veronique, Pissaloux, Daniel, Chen, Xu, Cerroni, Lorenzo, Judson, Robert L., LeBoit, Philip E., McCalmont, Timothy H., Bastian, Boris C., de la Fouchardière, Arnaud
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608693/
https://ncbi.nlm.nih.gov/pubmed/28935960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00758-3
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