NTRK3 kinase fusions in Spitz tumours

Oncogenic fusions in TRK family receptor tyrosine kinases have been identified in several cancers and can serve as therapeutic targets. We identified ETV6-NTRK3, MYO5A-NTRK3 and MYH9-NTRK3 fusions in Spitz tumours and demonstrate that NTRK3 fusions constitutively activate the MAPK, PI3K and PLCγ1 pa...

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Publicat a:J Pathol
Autors principals: Yeh, Iwei, Tee, Meng Kian, Botton, Thomas, Shain, A. Hunter, Sparatta, Alyssa J., Gagnon, Alexander, Vemula, Swapna S., Garrido, Maria C., Nakamaru, Kenji, Isoyama, Takeshi, McCalmont, Timothy H., LeBoit, Philip E., Bastian, Boris C.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071153/
https://ncbi.nlm.nih.gov/pubmed/27477320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4775
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