Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

In melanoma, therapies with inhibitors to oncogenic BRAF(V600E) are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of acquired drug resistance through the tumor microenvironment, which is mediated by huma...

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Publicado no:Nat Commun
Main Authors: Somasundaram, Rajasekharan, Zhang, Gao, Fukunaga-Kalabis, Mizuho, Perego, Michela, Krepler, Clemens, Xu, Xiaowei, Wagner, Christine, Hristova, Denitsa, Zhang, Jie, Tian, Tian, Wei, Zhi, Liu, Qin, Garg, Kanika, Griss, Johannes, Hards, Rufus, Maurer, Margarita, Hafner, Christine, Mayerhöfer, Marius, Karanikas, Georgios, Jalili, Ahmad, Bauer-Pohl, Verena, Weihsengruber, Felix, Rappersberger, Klemens, Koller, Josef, Lang, Roland, Hudgens, Courtney, Chen, Guo, Tetzlaff, Michael, Wu, Lawrence, Frederick, Dennie Tompers, Scolyer, Richard A., Long, Georgina V., Damle, Manashree, Ellingsworth, Courtney, Grinman, Leon, Choi, Harry, Gavin, Brian J., Dunagin, Margaret, Raj, Arjun, Scholler, Nathalie, Gross, Laura, Beqiri, Marilda, Bennett, Keiryn, Watson, Ian, Schaider, Helmut, Davies, Michael A., Wargo, Jennifer, Czerniecki, Brian J., Schuchter, Lynn, Herlyn, Dorothee, Flaherty, Keith, Herlyn, Meenhard, Wagner, Stephan N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605714/
https://ncbi.nlm.nih.gov/pubmed/28928360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00452-4
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