High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

BACKGROUND: Mechanical overloading can lead to disc degeneration. Nucleus pulposus (NP) cell senescence is aggravated within the degenerated disc. This study was designed to investigate the effects of high compression on NP cell senescence and the underlying molecular mechanism of this process. METH...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Li, Pei, Hou, Gang, Zhang, Ruijie, Gan, Yibo, Xu, Yuan, Song, Lei, Zhou, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604423/
https://ncbi.nlm.nih.gov/pubmed/28923094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1384-z
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