17beta-estradiol Attenuates TNF-α-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-κB Pathway

Background: Accelerated cellular senescence within the nucleus pulposus (NP) region is a common feature of disc degeneration. Our previous work indicated that TNF-α promoted NP cell senescence. Although the intervertebral disc has been reported to be an estrogen-sensitive tissue, it is unclear wheth...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Li, Pei, Gan, Yibo, Xu, Yuan, Wang, Liyuan, Ouyang, Bin, Zhang, Chengmin, Luo, Lei, Zhao, Chen, Zhou, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332869/
https://ncbi.nlm.nih.gov/pubmed/28255267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.16770
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