High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

BACKGROUND: Mechanical overloading can lead to disc degeneration. Nucleus pulposus (NP) cell senescence is aggravated within the degenerated disc. This study was designed to investigate the effects of high compression on NP cell senescence and the underlying molecular mechanism of this process. METH...

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Veröffentlicht in:Arthritis Res Ther
Hauptverfasser: Li, Pei, Hou, Gang, Zhang, Ruijie, Gan, Yibo, Xu, Yuan, Song, Lei, Zhou, Qiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604423/
https://ncbi.nlm.nih.gov/pubmed/28923094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1384-z
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