High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

BACKGROUND: Mechanical overloading can lead to disc degeneration. Nucleus pulposus (NP) cell senescence is aggravated within the degenerated disc. This study was designed to investigate the effects of high compression on NP cell senescence and the underlying molecular mechanism of this process. METH...

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Enregistré dans:
Détails bibliographiques
Publié dans:Arthritis Res Ther
Auteurs principaux: Li, Pei, Hou, Gang, Zhang, Ruijie, Gan, Yibo, Xu, Yuan, Song, Lei, Zhou, Qiang
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604423/
https://ncbi.nlm.nih.gov/pubmed/28923094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1384-z
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