Mixed Aryl Phosphonate Prodrugs of a Butyrophilin Ligand

[Image: see text] Studies of aryl phosphonate derivatives of a butyrophilin 3A1 ligand have resulted in identification of a potent stimulant of Vγ9 Vδ2 T cells. This compound, a mixed ester bearing one pivaloyloxymethyl substituent and one 1-naphthyl ester displayed an EC(50) of 0.79 nM as a stimula...

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Udgivet i:ACS Med Chem Lett
Main Authors: Foust, Benjamin J., Poe, Michael M., Lentini, Nicholas A., Hsiao, Chia-Hung Christine, Wiemer, Andrew J., Wiemer, David F.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601366/
https://ncbi.nlm.nih.gov/pubmed/28947936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00245
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