Epigenetically Aberrant Stroma In MDS Propagates Disease Via Wnt/β-Catenin Activation

The bone marrow microenvironment influences malignant hematopoiesis but how it promotes leukemogenesis has not been elucidated. Additionally, the role of the bone marrow stroma in regulating clinical responses to DNA methyltransferase inhibitors (DNMTi) is also poorly understood. In this study, we c...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Bhagat, Tushar D., Chen, Si, Bartenstein, Matthias, Barlowe, A., Trevor, Von Ahrens, Dagny, Choudhary, Gaurav S., Tivnan, Patrick, Amin, Elianna, Marcondes, Mario, Sanders, Mathijs A., Hoogenboezem, Remco M., Kambhampati, Suman, Ramachandra, Nandini, Mantzaris, Iaonnis, Sukrithan, Vineeth, Laurence, Remi, Lopez, Robert, Bhagat, Prafullla, Giricz, Orsi, Sohal, Davendra, Wickrema, Amittha, Yeung, Cecilia, Gritsman, Kira, Aplan, Peter, Hochedlinger, Konrad, Yu, Yiting, Pradhan, Kith, Zhang, Jinghang, Greally, John M., Mukherjee, Siddhartha, Pellagatti, Andrea, Boultwood, Jacqueline, Will, Britta, Steidl, Ulrich, Raaijmakers, Marc H.G.P., Deeg, H. Joachim, Kharas, Michael G., Verma, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600853/
https://ncbi.nlm.nih.gov/pubmed/28684528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0282
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