Epigenetically Aberrant Stroma In MDS Propagates Disease Via Wnt/β-Catenin Activation

The bone marrow microenvironment influences malignant hematopoiesis but how it promotes leukemogenesis has not been elucidated. Additionally, the role of the bone marrow stroma in regulating clinical responses to DNA methyltransferase inhibitors (DNMTi) is also poorly understood. In this study, we c...

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Publicat a:Cancer Res
Autors principals: Bhagat, Tushar D., Chen, Si, Bartenstein, Matthias, Barlowe, A., Trevor, Von Ahrens, Dagny, Choudhary, Gaurav S., Tivnan, Patrick, Amin, Elianna, Marcondes, Mario, Sanders, Mathijs A., Hoogenboezem, Remco M., Kambhampati, Suman, Ramachandra, Nandini, Mantzaris, Iaonnis, Sukrithan, Vineeth, Laurence, Remi, Lopez, Robert, Bhagat, Prafullla, Giricz, Orsi, Sohal, Davendra, Wickrema, Amittha, Yeung, Cecilia, Gritsman, Kira, Aplan, Peter, Hochedlinger, Konrad, Yu, Yiting, Pradhan, Kith, Zhang, Jinghang, Greally, John M., Mukherjee, Siddhartha, Pellagatti, Andrea, Boultwood, Jacqueline, Will, Britta, Steidl, Ulrich, Raaijmakers, Marc H.G.P., Deeg, H. Joachim, Kharas, Michael G., Verma, Amit
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600853/
https://ncbi.nlm.nih.gov/pubmed/28684528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0282
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