Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks

Replicative helicases in all cell types are hexameric rings that unwind DNA by steric exclusion in which the helicase encircles the tracking strand only and excludes the other strand from the ring. This mode of translocation allows helicases to bypass blocks on the strand that is excluded from the c...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Langston, Lance D, Mayle, Ryan, Schauer, Grant D, Yurieva, Olga, Zhang, Daniel, Yao, Nina Y, Georgescu, Roxana E, O'Donnell, Mike E
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2017
Matèries:
Biochemistry and Chemical Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599239/
https://ncbi.nlm.nih.gov/pubmed/28869037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29118
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