Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks

Replicative helicases in all cell types are hexameric rings that unwind DNA by steric exclusion in which the helicase encircles the tracking strand only and excludes the other strand from the ring. This mode of translocation allows helicases to bypass blocks on the strand that is excluded from the c...

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Bibliographic Details
Published in:eLife
Main Authors: Langston, Lance D, Mayle, Ryan, Schauer, Grant D, Yurieva, Olga, Zhang, Daniel, Yao, Nina Y, Georgescu, Roxana E, O'Donnell, Mike E
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Biochemistry and Chemical Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599239/
https://ncbi.nlm.nih.gov/pubmed/28869037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29118
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