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BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
Mutations in the tumor suppressor BRCA2 predominantly predispose to breast cancer. Paradoxically, while loss of BRCA2 promotes tumor formation, it also causes cell lethality, although how lethality is triggered is unclear. Here, we generate BRCA2 conditional non-transformed human mammary epithelial...
में बचाया:
| में प्रकाशित: | Nat Commun |
|---|---|
| मुख्य लेखकों: | , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group UK
2017
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5597640/ https://ncbi.nlm.nih.gov/pubmed/28904335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00634-0 |
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