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Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer
Germ-line and somatic mutations in genes that promote homology-directed repair (HDR), especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular, breast and ovary but also prostate and other cancers. HDR is critical for the error-free repair of DNA double-strand breaks and...
Shranjeno v:
| izdano v: | Annu Rev Cancer Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6193498/ https://ncbi.nlm.nih.gov/pubmed/30345412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-cancerbio-030617-050502 |
| Oznake: |
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