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Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer

Germ-line and somatic mutations in genes that promote homology-directed repair (HDR), especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular, breast and ovary but also prostate and other cancers. HDR is critical for the error-free repair of DNA double-strand breaks and...

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Detalhes bibliográficos
Publicado no:Annu Rev Cancer Biol
Main Authors: Chen, Chun-Chin, Feng, Weiran, Lim, Pei Xin, Kass, Elizabeth M., Jasin, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193498/
https://ncbi.nlm.nih.gov/pubmed/30345412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-cancerbio-030617-050502
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