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Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins
Homologous recombination (HR) is a major pathway for the repair of DNA double-strand breaks in mammalian cells, the defining step of which is homologous strand exchange directed by the RAD51 protein. The physiological importance of HR is underscored by the observation of genomic instability in HR-de...
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| Publicado no: | Cold Spring Harb Perspect Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4382744/ https://ncbi.nlm.nih.gov/pubmed/25833843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a016600 |
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