Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure

Vδ2(+) γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria. The role of these cells in mediating clinical immunity (i.e. protection against symptoms) to mala...

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Published in:Sci Rep
Main Authors: Jagannathan, Prasanna, Lutwama, Fredrick, Boyle, Michelle J., Nankya, Felistas, Farrington, Lila A., McIntyre, Tara I., Bowen, Katherine, Naluwu, Kate, Nalubega, Mayimuna, Musinguzi, Kenneth, Sikyomu, Esther, Budker, Rachel, Katureebe, Agaba, Rek, John, Greenhouse, Bryan, Dorsey, Grant, Kamya, Moses R., Feeney, Margaret E.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5597587/
https://ncbi.nlm.nih.gov/pubmed/28904345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10624-3
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