Frequent Malaria Drives Progressive Vδ2 T-Cell Loss, Dysfunction, and CD16 Up-regulation During Early Childhood

γδ T cells expressing Vδ2 may be instrumental in the control of malaria, because they inhibit the replication of blood-stage parasites in vitro and expand during acute malaria infection. However, Vδ2 T-cell frequencies and function are lower among children with heavy prior malaria exposure. It remai...

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發表在:J Infect Dis
Main Authors: Farrington, Lila A., Jagannathan, Prasanna, McIntyre, Tara I., Vance, Hilary M., Bowen, Katherine, Boyle, Michelle J., Nankya, Felistas, Wamala, Samuel, Auma, Ann, Nalubega, Mayimuna, Sikyomu, Esther, Naluwu, Kate, Bigira, Victor, Kapisi, James, Dorsey, Grant, Kamya, Moses R., Feeney, Margaret E.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2016
主題:
Major Articles and Brief Reports
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813738/
https://ncbi.nlm.nih.gov/pubmed/26667315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv600
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