Frequent Malaria Drives Progressive Vδ2 T-Cell Loss, Dysfunction, and CD16 Up-regulation During Early Childhood

γδ T cells expressing Vδ2 may be instrumental in the control of malaria, because they inhibit the replication of blood-stage parasites in vitro and expand during acute malaria infection. However, Vδ2 T-cell frequencies and function are lower among children with heavy prior malaria exposure. It remai...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Farrington, Lila A., Jagannathan, Prasanna, McIntyre, Tara I., Vance, Hilary M., Bowen, Katherine, Boyle, Michelle J., Nankya, Felistas, Wamala, Samuel, Auma, Ann, Nalubega, Mayimuna, Sikyomu, Esther, Naluwu, Kate, Bigira, Victor, Kapisi, James, Dorsey, Grant, Kamya, Moses R., Feeney, Margaret E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813738/
https://ncbi.nlm.nih.gov/pubmed/26667315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv600
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