Frequent Malaria Drives Progressive Vδ2 T-Cell Loss, Dysfunction, and CD16 Up-regulation During Early Childhood

γδ T cells expressing Vδ2 may be instrumental in the control of malaria, because they inhibit the replication of blood-stage parasites in vitro and expand during acute malaria infection. However, Vδ2 T-cell frequencies and function are lower among children with heavy prior malaria exposure. It remai...

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Bibliographic Details
Published in:J Infect Dis
Main Authors: Farrington, Lila A., Jagannathan, Prasanna, McIntyre, Tara I., Vance, Hilary M., Bowen, Katherine, Boyle, Michelle J., Nankya, Felistas, Wamala, Samuel, Auma, Ann, Nalubega, Mayimuna, Sikyomu, Esther, Naluwu, Kate, Bigira, Victor, Kapisi, James, Dorsey, Grant, Kamya, Moses R., Feeney, Margaret E.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Major Articles and Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813738/
https://ncbi.nlm.nih.gov/pubmed/26667315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv600
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