Frequent Malaria Drives Progressive Vδ2 T-Cell Loss, Dysfunction, and CD16 Up-regulation During Early Childhood

γδ T cells expressing Vδ2 may be instrumental in the control of malaria, because they inhibit the replication of blood-stage parasites in vitro and expand during acute malaria infection. However, Vδ2 T-cell frequencies and function are lower among children with heavy prior malaria exposure. It remai...

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Dades bibliogràfiques
Publicat a:J Infect Dis
Autors principals: Farrington, Lila A., Jagannathan, Prasanna, McIntyre, Tara I., Vance, Hilary M., Bowen, Katherine, Boyle, Michelle J., Nankya, Felistas, Wamala, Samuel, Auma, Ann, Nalubega, Mayimuna, Sikyomu, Esther, Naluwu, Kate, Bigira, Victor, Kapisi, James, Dorsey, Grant, Kamya, Moses R., Feeney, Margaret E.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Major Articles and Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813738/
https://ncbi.nlm.nih.gov/pubmed/26667315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv600
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