Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria

FoxP3+ regulatory CD4 T cells (T(regs)) help to maintain the delicate balance between pathogen-specific immunity and immune-mediated pathology. Prior studies suggest that T(regs) are induced by P. falciparum both in vivo and in vitro; however, the factors influencing T(reg) homeostasis during acute...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Boyle, Michelle J., Jagannathan, Prasanna, Farrington, Lila A., Eccles-James, Ijeoma, Wamala, Samuel, McIntyre, Tara I, Vance, Hilary M., Bowen, Katherine, Nankya, Felistas, Auma, Ann, Nalubega, Mayimuna, Sikyomu, Esther, Naluwu, Kate, Rek, John, Katureebe, Agaba, Bigira, Victor, Kapisi, James, Tappero, Jordan, Muhindo, Mary K, Greenhouse, Bryan, Arinaitwe, Emmanuel, Dorsey, Grant, Kamya, Moses R., Feeney, Margaret E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504515/
https://ncbi.nlm.nih.gov/pubmed/26182204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005041
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