Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria

FoxP3+ regulatory CD4 T cells (T(regs)) help to maintain the delicate balance between pathogen-specific immunity and immune-mediated pathology. Prior studies suggest that T(regs) are induced by P. falciparum both in vivo and in vitro; however, the factors influencing T(reg) homeostasis during acute...

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Pubblicato in:PLoS Pathog
Autori principali: Boyle, Michelle J., Jagannathan, Prasanna, Farrington, Lila A., Eccles-James, Ijeoma, Wamala, Samuel, McIntyre, Tara I, Vance, Hilary M., Bowen, Katherine, Nankya, Felistas, Auma, Ann, Nalubega, Mayimuna, Sikyomu, Esther, Naluwu, Kate, Rek, John, Katureebe, Agaba, Bigira, Victor, Kapisi, James, Tappero, Jordan, Muhindo, Mary K, Greenhouse, Bryan, Arinaitwe, Emmanuel, Dorsey, Grant, Kamya, Moses R., Feeney, Margaret E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504515/
https://ncbi.nlm.nih.gov/pubmed/26182204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005041
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