Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria

FoxP3+ regulatory CD4 T cells (T(regs)) help to maintain the delicate balance between pathogen-specific immunity and immune-mediated pathology. Prior studies suggest that T(regs) are induced by P. falciparum both in vivo and in vitro; however, the factors influencing T(reg) homeostasis during acute...

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Gepubliceerd in:PLoS Pathog
Hoofdauteurs: Boyle, Michelle J., Jagannathan, Prasanna, Farrington, Lila A., Eccles-James, Ijeoma, Wamala, Samuel, McIntyre, Tara I, Vance, Hilary M., Bowen, Katherine, Nankya, Felistas, Auma, Ann, Nalubega, Mayimuna, Sikyomu, Esther, Naluwu, Kate, Rek, John, Katureebe, Agaba, Bigira, Victor, Kapisi, James, Tappero, Jordan, Muhindo, Mary K, Greenhouse, Bryan, Arinaitwe, Emmanuel, Dorsey, Grant, Kamya, Moses R., Feeney, Margaret E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504515/
https://ncbi.nlm.nih.gov/pubmed/26182204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005041
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