Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4(+) T Cells and Limits Their Production of Immunoregulatory Interleukin 10

Background. Experimental inoculation of viable Plasmodium falciparum sporozoites administered with chemoprevention targeting blood-stage parasites results in protective immunity. It is unclear whether chemoprevention similarly enhances immunity following natural exposure to malaria. Methods. We asse...

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Vydáno v:J Infect Dis
Hlavní autoři: Jagannathan, Prasanna, Bowen, Katherine, Nankya, Felistas, McIntyre, Tara I., Auma, Ann, Wamala, Samuel, Sikyomu, Esther, Naluwu, Kate, Nalubega, Mayimuna, Boyle, Michelle J., Farrington, Lila A., Bigira, Victor, Kapisi, James, Aweeka, Fran, Greenhouse, Bryan, Kamya, Moses, Dorsey, Grant, Feeney, Margaret E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918829/
https://ncbi.nlm.nih.gov/pubmed/27067196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiw147
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