Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4(+) T Cells and Limits Their Production of Immunoregulatory Interleukin 10

Background. Experimental inoculation of viable Plasmodium falciparum sporozoites administered with chemoprevention targeting blood-stage parasites results in protective immunity. It is unclear whether chemoprevention similarly enhances immunity following natural exposure to malaria. Methods. We asse...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Jagannathan, Prasanna, Bowen, Katherine, Nankya, Felistas, McIntyre, Tara I., Auma, Ann, Wamala, Samuel, Sikyomu, Esther, Naluwu, Kate, Nalubega, Mayimuna, Boyle, Michelle J., Farrington, Lila A., Bigira, Victor, Kapisi, James, Aweeka, Fran, Greenhouse, Bryan, Kamya, Moses, Dorsey, Grant, Feeney, Margaret E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918829/
https://ncbi.nlm.nih.gov/pubmed/27067196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiw147
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