Effector Phenotype of Plasmodium falciparum–Specific CD4(+) T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations

Background. Mechanisms mediating immunity to malaria remain unclear, but animal data and experimental human vaccination models suggest a critical role for CD4(+) T cells. Advances in multiparametric flow cytometry have revealed that the functional quality of pathogen-specific CD4(+) T cells determin...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Infect Dis
Auteurs principaux: Boyle, Michelle J., Jagannathan, Prasanna, Bowen, Katherine, McIntyre, Tara I., Vance, Hilary M., Farrington, Lila A., Greenhouse, Bryan, Nankya, Felistas, Rek, John, Katureebe, Agaba, Arinaitwe, Emmanuel, Dorsey, Grant, Kamya, Moses R., Feeney, Margaret E.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Major Articles and Brief Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539911/
https://ncbi.nlm.nih.gov/pubmed/25646355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv054
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