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Effector Phenotype of Plasmodium falciparum–Specific CD4(+) T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations

Background. Mechanisms mediating immunity to malaria remain unclear, but animal data and experimental human vaccination models suggest a critical role for CD4(+) T cells. Advances in multiparametric flow cytometry have revealed that the functional quality of pathogen-specific CD4(+) T cells determin...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Boyle, Michelle J., Jagannathan, Prasanna, Bowen, Katherine, McIntyre, Tara I., Vance, Hilary M., Farrington, Lila A., Greenhouse, Bryan, Nankya, Felistas, Rek, John, Katureebe, Agaba, Arinaitwe, Emmanuel, Dorsey, Grant, Kamya, Moses R., Feeney, Margaret E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539911/
https://ncbi.nlm.nih.gov/pubmed/25646355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv054
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