Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure

Vδ2(+) γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria. The role of these cells in mediating clinical immunity (i.e. protection against symptoms) to mala...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Jagannathan, Prasanna, Lutwama, Fredrick, Boyle, Michelle J., Nankya, Felistas, Farrington, Lila A., McIntyre, Tara I., Bowen, Katherine, Naluwu, Kate, Nalubega, Mayimuna, Musinguzi, Kenneth, Sikyomu, Esther, Budker, Rachel, Katureebe, Agaba, Rek, John, Greenhouse, Bryan, Dorsey, Grant, Kamya, Moses R., Feeney, Margaret E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5597587/
https://ncbi.nlm.nih.gov/pubmed/28904345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10624-3
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