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Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms

The influenza A virus nucleoprotein (NP) is an essential multifunctional protein that encapsidates the viral genome and functions as an adapter between the virus and the host cell machinery. NPs from all strains of influenza A viruses contain two nuclear localization signals (NLSs): a well-studied m...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Wu, Wei, Sankhala, Rajeshwer S., Florio, Tyler J., Zhou, Lixin, Nguyen, Nhan L. T., Lokareddy, Ravi K., Cingolani, Gino, Panté, Nelly
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595889/
https://ncbi.nlm.nih.gov/pubmed/28900157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11018-1
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