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Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms

The influenza A virus nucleoprotein (NP) is an essential multifunctional protein that encapsidates the viral genome and functions as an adapter between the virus and the host cell machinery. NPs from all strains of influenza A viruses contain two nuclear localization signals (NLSs): a well-studied m...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Wu, Wei, Sankhala, Rajeshwer S., Florio, Tyler J., Zhou, Lixin, Nguyen, Nhan L. T., Lokareddy, Ravi K., Cingolani, Gino, Panté, Nelly
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595889/
https://ncbi.nlm.nih.gov/pubmed/28900157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11018-1
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