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Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
Active nuclear import of Ran exchange factor RCC1 is mediated by importin α3. This pathway is essential to generate a gradient of RanGTP on chromatin that directs nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Here we identify the mechanisms of importin α3 sele...
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| Gepubliceerd in: | Nat Commun |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5645467/ https://ncbi.nlm.nih.gov/pubmed/29042532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01057-7 |
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