Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1

Active nuclear import of Ran exchange factor RCC1 is mediated by importin α3. This pathway is essential to generate a gradient of RanGTP on chromatin that directs nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Here we identify the mechanisms of importin α3 sele...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Sankhala, Rajeshwer S., Lokareddy, Ravi K., Begum, Salma, Pumroy, Ruth A., Gillilan, Richard E., Cingolani, Gino
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645467/
https://ncbi.nlm.nih.gov/pubmed/29042532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01057-7
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